Preventive & longevity medicine in Newtown, PA
A coordinated annual plan that catches what a standard physical misses — and integrates advanced screening that most primary care practices can’t order.
Through the Private Physicians Alliance, Signature Medicine members can layer advanced screening — Prenuvo whole-body MRI, Galleri multi-cancer early detection, Natera and MyOme genomics, New Amsterdam Genomics, Empower Sleep, and InBody body composition — onto a guideline-driven preventive plan that Dr. Sitapara owns end-to-end.
The annual preventive plan
Every member gets an extended annual visit with Dr. Sitapara. The plan is built from your personal and family history, last year’s findings, and the current evidence. Guideline-recommended screening is ordered and tracked — mammography, colonoscopy, age- and risk-appropriate labs — and follow-up is closed out, not left in your inbox.
The advanced-screening layer
For members who want depth beyond guidelines, the PPA partner network is where Signature Medicine has real differentiation. Each partner is vetted, ordered through Dr. Sitapara, and interpreted in the context of your full chart:
- Prenuvo — whole-body MRI for early-stage disease screening
- Grail Galleri — single-blood-test multi-cancer early detection for shared cancer signal across 50+ types
- Natera — clinical genetic testing across hereditary cancer, prenatal, and tumor-informed cancer monitoring
- MyOme — whole-genome platform, re-queried as new clinical evidence emerges
- New Amsterdam Genomics — adult cardiovascular and pharmacogenomic risk
- Empower Sleep — at-home sleep-apnea diagnostics
- InBody — clinical body-composition tracking
Who this is built for
Adults serious about prevention; patients with a family history that argues for earlier and broader screening; people in their 40s–60s who want to push back the onset of age-related disease with data rather than guesswork. For relatively healthy younger adults without specific risk factors, much of the value comes from the longitudinal relationship and coordination, not the partner roster.
Frequently Asked Questions
What is preventive and longevity medicine at Signature Medicine?
A coordinated annual preventive plan that goes beyond the standard physical. It combines guideline-driven screening (USPSTF-recommended, age- and risk-appropriate) with optional advanced screening through the Private Physicians Alliance — Prenuvo whole-body MRI, Galleri multi-cancer early detection, Natera and MyOme genetic testing, New Amsterdam Genomics for cardiovascular and pharmacogenomic risk, and Empower Sleep for sleep-apnea screening.
How is this different from an executive physical at a hospital system?
Hospital executive-physical programs typically deliver a battery of tests in one day, then hand you a binder. The follow-up is up to you. Signature Medicine integrates advanced screening into a longitudinal plan — Dr. Sitapara is the ordering and interpreting physician, the results stay in your chart, and the next-year plan adjusts based on what we found.
Do I need every PPA partner service?
No. The partner roster is a menu, not a checklist. Dr. Sitapara only surfaces a service when it fits your specific situation — for example, Galleri is more useful for someone with a strong family history of cancer; Prenuvo is more useful for symptom investigation or longevity-focused patients; MyOme makes sense when pharmacogenomics or inherited risk is in play.
How does the InBody scan fit in?
Body composition is a stronger longevity marker than weight or BMI alone. The InBody scan tracks skeletal muscle mass, visceral fat, and segmental balance across years. We use it to anchor weight-management plans, monitor age-related muscle loss, and quantify what your training is actually producing.
Is this covered by insurance?
The membership fee covers the planning, ordering, and interpretation of advanced screening. Most guideline-recommended screening (mammography, colonoscopy, age-appropriate labs) is billed to your insurance the same as in any primary care practice. PPA partner services (Prenuvo, Galleri, etc.) are typically paid at preferred-member rates directly to the partner — Medicare and commercial plans rarely cover them.
Last reviewed by Dr. Ashish Sitapara, MD, FACP on